MPP (dihydrochloride)
CAS No. : 911295-24-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $420 | In-stock |
| 50mg | $710 | In-stock |
| 100mg | $970 | In-stock |
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| Cat. No. : | HY-103454 |
| M.Wt: | 542.50 |
| Formula: | C29H33Cl2N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 30 mg/mL (ultrasonic;warming) |
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3].
In Vitro:MPP (1, 5, 10, 25, 50 and 100 µM; 24 h) decreases cell viability with an IC50 value of 20.01 µM in RL95-2 cells[1].
MPP dihydrochloride shows antiproliferative activity at a concentration of 10 μM in RL95-2 cells[1].
MPP dihydrochloride (20 µM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα[1].
In Vivo:MPP (Low dose 20 μg/kg body weight or high dose 200 μg/kg body weight) leads to a dose-dependent attenuation of percent prepulse inhibition (PPI)[2].
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