SB 706504
CAS No. : 911110-38-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | Get quote |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-108644 |
| M.Wt: | 492.46 |
| Formula: | C24H19F3N8O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD)[1].
In Vitro:SB 706504(3 μM, 6 h) significantly reduces IL-1β, IL-6, GM-CSF, TNFα and IL-8 mRNA levels in LPS-stimulated monocyte derived macrophages (MDMs) cells[1].
SB 706504(3 μM, 6 h) can significantly reduce the level of TNFα induced by LPS in ?alveolar macrophages (AMs) cells of COPD patients, with an inhibition rate of 67.4%[1].
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