Litronesib
CAS No. : 910634-41-2
(Synonyms: LY2523355)
| Size | Price | Stock |
|---|---|---|
| 5mg | $132 | In-stock |
| 10mg | $228 | In-stock |
| 25mg | $497 | In-stock |
| 50mg | $695 | In-stock |
| 100mg | $970 | In-stock |
| 1g | $2900 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-14846 |
| M.Wt: | 511.70 |
| Formula: | C23H37N5O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity[1]. IC50 & Target: Eg5[1] In Vitro: Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC)[1]. In Vivo: Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].
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