Pyrilamine
CAS No. : 91-84-9
(Synonyms: Mepyramine)
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| Cat. No. : | HY-118807 |
| M.Wt: | 285.38 |
| Formula: | C17H23N3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pyrilamine is a potent histamine H1 antagonist. Pyrilamine can block sympathomimetic effects. Pyrilamine significantly reduces nicotine self-administration. Pyrilamine competitively inhibits nicotine uptake by TR-BBB13 cells with a Ki of 15 μM[1][2].
In Vivo: Pyrilamine (Sprague–Dawley rats, 40 mg/kg, once) significantly reduces nicotine self-administration[1].
Pyrilamine (Sprague–Dawley rats, 20 mg/kg, repeated injections; 50 mg/kg/day, continuous SC infusions with osmotic minipumps) significantly decreases nicotine self-administration[1].
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