Methapyrilene
CAS No. : 91-80-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $96 | In-stock |
| 25mg | $192 | In-stock |
| 50mg | $307 | In-stock |
| 100mg | $490 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111130 |
| M.Wt: | 261.39 |
| Formula: | C14H19N3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].
In Vitro:Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1].
In Vivo:Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats[2].
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