Isatin
CAS No. : 91-56-5
(Synonyms: Indoline-2,3-dione)
| Size | Price | Stock |
|---|---|---|
| 25g | $19 | In-stock |
| 100g | $35 | In-stock |
| 500g | $41 | In-stock |
| 1000g | $77 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-Y0265 |
| M.Wt: | 147.13 |
| Formula: | C8H5NO2 |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3]. IC50 & Target: IC50: 3 μM (MAO B)[1] In Vitro: In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis[2]. In Vivo: A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations[3].
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