W146
CAS No. : 909725-61-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $750 | In-stock |
| 10mg | $1280 | In-stock |
| 25mg | $2560 | In-stock |
| 50mg | $3950 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-101395 |
| M.Wt: | 342.37 |
| Formula: | C16H27N2O4P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
IC50 & Target: EC50: 398 nM (S1PR1)[1].
In Vitro: W146 is a S1PR1 antagonist with a Ki of ~70-80 nM[1].
W146 pretreatment significantly increases activated cleaved caspase-3 levels. The reduced EPCs apoptosis which induced by S1P is completely abolished after treatment with W146[2].
In Vivo: W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone[3]
The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice[3].
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