CP-467688
CAS No. : 909576-25-6
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| Cat. No. : | HY-111159 |
| M.Wt: | 533.97 |
| Formula: | C27H27ClF3N3O3 |
| Purity: | >98 % |
| Solubility: |
CP-467688 is an orally active retinotoxic agent. CP-467688 induces increased lysosome volume, phagocytosis inhibition and autophagy inhibition in retinal cells. CP-467688 is applicable to the research of retinopathy[1].
In Vitro:CP-467688 (1.2-100.0 mM; 24 h) induces concentration-dependent lysosomal volume expansion in ARPE-19 cells[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits the phagocytic function of ARPE-19 cells[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits autophagic flux in ARPE-19 cells, with the peak punctate LC3 fluorescence intensity being approximately 5 times that of the control group[1].
In Vivo:CP-467688 (100-500 mg/kg; p.o.; daily; 7-14 days) induces retinal toxicity in male Sprague-Dawley rats, as evidenced by vacuolization and disruption of the RPE layer[1].
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