α-CGRP (human)
CAS No. : 90954-53-3
(Synonyms: Calcitonin gene-related peptide)
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|---|---|---|
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| 5mg | $350 | In-stock |
| 10mg | $560 | In-stock |
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| Cat. No. : | HY-P1071 |
| M.Wt: | 3789.31 |
| Formula: | C163H267N51O49S2 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic) |
α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects[1][2][3].
In Vitro: α-CGRP (human) (3×10-11-3×10-9 moles; 45 s) can decrease the coronary perfusion pressure and increase the heart rate of isolated rat hearts, but has no significant effect on the contractility of isolated rat hearts[1].
α-CGRP (human) (3×10-11-3×10-9 moles; 45 s) can decrease the coronary perfusion pressure of isolated rabbit hearts, but has no significant effect on the heart rate and contractility of isolated rabbit hearts[1].
In Vivo: α-CGRP (human) (Intravenous infusion; 0.03 nmol/kg/min; 60 min) can cause significant hypotension and tachycardia accompanied by falls in renal and mesenteric flows, but an increase in hindquarters flow, and a transient renal, sustained hindquarters vasodilatation and a mesenteric vasoconstriction in conscious rats[2].
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