Broussonin E
CAS No. : 90902-21-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $580 | In-stock |
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| Cat. No. : | HY-N2963 |
| M.Wt: | 288.34 |
| Formula: | C17H20O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].
In Vitro:Broussonin E (20 μM, 3 h) inhibits the LPS (Lipopolysaccharides, HY-D1056)-stimulated phosphorylation of ERK and p38 MAPK[1].
Broussonin E can activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3[1].
Broussonin E (0-20 μM, 3 h) can suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS[1].
Broussonin E enhances the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells[1].
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