MLS-2064
CAS No. : 906660-74-0
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| Cat. No. : | HY-111168 |
| M.Wt: | 541.27 |
| Formula: | C22H24BrCl2N5O2 |
| Purity: | >98 % |
| Solubility: |
MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma[1].
In Vitro:MLS-2064 (compound 13j) (8 h) potently reduces the viability of various human tumor cell lines and embryonic kidney cell lines[1].
MLS-2064 (48 h) induces caspase-independent cell death in SH-SY5Y cells, as its cell viability inhibitory activity is not affected by the caspase inhibitor Q-VD-OPh[1].
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