SMBA1


CAS No. : 906440-37-7

906440-37-7
Price and Availability of CAS No. : 906440-37-7
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1mg $190 Get quote
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10mg $668 Get quote
25mg $1097 Get quote
50mg $1559 Get quote
100mg $2136 Get quote
500mg $4262 Get quote
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Cat. No. : HY-101996
M.Wt: 315.32
Formula: C20H13NO3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 906440-37-7 :

SMBA1 is a potent Bax agonist with a Ki value of 43.3 nM. SMBA1 enhances the Bax expression. SMBA1 shows anti-tumor activity. SMBA1 has the potential for the research of lung cancer[1]. In Vitro:SMBA1 induces conformational changes in Bax by blocking S184 phosphorylation, facilitating Bax insertion into mitochondrial membranes and forming Bax oligomers shows Bax agonist activity[1].
. SMBA1 (0, 0.1, 1, 5, 10 µM; 24 h) enhances the Bax expression in a dose-dependent manner in A549 cells[1]. In Vivo:SMBA1 (2, 10, 40, 60 mg/kg; i.p.; once daily for 10 days) shows anti-tumor activity in mouse[1].

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