Diprotin A
CAS No. : 90614-48-5
(Synonyms: Ile-Pro-Ile)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $70 | In-stock |
| 25mg | $120 | In-stock |
| 50mg | $190 | In-stock |
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| Cat. No. : | HY-111174 |
| M.Wt: | 341.45 |
| Formula: | C17H31N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1]. IC50 & Target:IC50: DPP-IV[1] In Vitro: Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1]. In Vivo: Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].
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