| Size | Price | Stock |
|---|---|---|
| 1mg | $135 | In-stock |
| 5mg | $400 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-B0603 |
| M.Wt: | 444.51 |
| Formula: | C22H27F3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].
In Vitro: Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC50 value of 99 nM[2].
Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release[3].
In Vivo: Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion[4].
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