Fluticasone


CAS No. : 90566-53-3

90566-53-3
Price and Availability of CAS No. : 90566-53-3
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1mg $135 In-stock
5mg $400 In-stock
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Cat. No. : HY-B0603
M.Wt: 444.51
Formula: C22H27F3O4S
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 90566-53-3 :

Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2]. In Vitro: Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC50 value of 99 nM[2].
Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release[3]. In Vivo: Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion[4].

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