Pevonedistat (Standard)
CAS No. : 905579-51-3
(Synonyms: MLN4924 (Standard))
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| Cat. No. : | HY-70062R |
| M.Wt: | 443.52 |
| Formula: | C21H25N5O4S |
| Purity: | >98 % |
| Solubility: |
Pevonedistat (Standard) is the analytical standard of Pevonedistat. This product is intended for research and analytical applications. Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice[1]. IC50 & Target:IC50: 4.7 nM (NAE)[1]
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