Pancreatic Polypeptide, rat
CAS No. : 90419-12-8
(Synonyms: Rat pancreatic polypeptide)
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| Cat. No. : | HY-P1532 |
| M.Wt: | 4398.87 |
| Formula: | C195H298N58O57S |
| Purity: | >98 % |
| Solubility: | 10 mM in H2O |
Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. IC50 & Target:NPYR4[1] In Vitro: Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca2+)i levels in BRIN BD11 cells at 1 μM[1]. In Vivo: Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice[1].
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