Bicalutamide
CAS No. : 90357-06-5
| Size | Price | Stock |
|---|---|---|
| 100mg | $55 | In-stock |
| 500mg | $88 | In-stock |
| 1g | $110 | In-stock |
| 5g | $275 | In-stock |
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| Cat. No. : | HY-14249 |
| M.Wt: | 430.37 |
| Formula: | C18H14F4N2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer[1].
IC50 & Target: Androgen receptor[1]
In Vitro: Bicalutamide competes with androgens for binding AR in in a whole-cell binding-assay (LNCaP/AR(cs) cells), with an IC50 of 160 nM[1].
Bicalutamide induces proliferation of VCaP cells in a dose-dependent manner, whereas partially antagonizes the effects of R1881 (synthetic androgen)[1].
In Vivo: Bicalutamide (10 mg/kg; i.g.; daily; for 28 days) exhibits anti-tumor activity in prostate cancer mice model[1].
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