FPA-124
CAS No. : 902779-59-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $230 | In-stock |
| 10mg | $340 | In-stock |
| 25mg | $680 | In-stock |
| 50mg | $1128 | In-stock |
| 100mg | $1880 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15369 |
| M.Wt: | 381.73 |
| Formula: | C11H9Cl2CuN3O2S |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis[1][2]. In Vitro: FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively[1]. In Vivo: FPA-124 exhibits PKB (Akt protein) inhibitory activities and causes NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells[1].
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