Neocarzinostatin (solution)
CAS No. : 9014-02-2
(Synonyms: Zinostatin; Vinostatin)
| Size | Price | Stock |
|---|---|---|
| 100μg | $1700 | Get quote |
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| Cat. No. : | HY-111183 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Neocarzinostatin (solution), a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment [1][2].
In Vitro:The EpCAM aptamer conjugated Neocarzinostatin (NCS) shows specificity to EpCAM-positive cells. The effects of the conjugates on cancer cells are impressive as the conjugate arrests the cell cycle and promoted apoptosis and necrosis. The high levels of PARP expression confirmed the DNA breaks upon conjugate treatment. NCS conjugated with EpCAM can be targeted to cancer cells sparing normal cells[3].
Nerve growth factor (NGF) (100-1000 ng/mL) protects SK-N-SH cells from the morphological and cytocidal effects of Neocarzinostatin (1-hr exposure, 0.017 to 0.033 μg/mL)[4].
In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3[5].
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