Chitosan (≥90% deacetylated,viscosity 650-700 mPa.s)

Chitosan (Deacetylated chitin) (≥90% deacetylated, viscosity 650-700 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated, viscosity 650-700 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing^[1][2][3]. In Vitro:Low-molecular-weight chitosan can penetrate bacterial cell walls, bind with DNA and inhibit DNA transcription and mRNA synthesis, while high-molecular-weight Chitosan can bind to the negatively charged components on the bacterial cell wall. It forms an impermeable layer around the cell, changes cell permeability and blocks transport into the cell. Chitosan also can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity research and as a scaffold for tissue engineering^[2]. In Vivo:In chemical-induced colonic precancerous lesions in ICR mice, in the 2 weeks preventive experiments, mice fed with a diet containing high molecular weight Chitosan (HMWC) had significant fewer aberrant crypt foci formation than those fed with control diet. As the treatment extended to 6 weeks, both low molecular weight Chitosan (LMWC)- and HMWC-fed mice contained less aberrant crypt foci when compared to control^[3].