Thyroglobulin

Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell^[1]. IC50 & Target:others In Vitro:Thyroglobulin (0-10 mg/mL; 12 h to 5 days) stimulates cell growth and DNA synthesis in quiescent FRTL-5 thyroid cells, with maximal activity at 5 mg/mL and reduced activity at higher concentrations^[1].
Thyroglobulin (5 mg/mL; 12 h) does not increase cAMP levels in FRTL-5 thyroid cells^[1].
Thyroglobulin (5 mg/mL; 30-180 min) activates Akt kinase activity in FRTL-5 thyroid cells within 30 min^[1].
Thyroglobulin (0-10 mg/mL) suppresses TPO promoter activity in FRTL-5 thyroid cells in vitro in a concentration-dependent manner^[1].
Thyroglobulin (0-10 mg/mL; 24 h) modulates PDS mRNA expression in FRTL-5 thyroid cells, with maximal expression at 5 mg/mL and reduced expression at higher concentrations^[1].