Rebamipide
CAS No. : 90098-04-7
(Synonyms: OPC12759; Proamipide)
| Size | Price | Stock |
|---|---|---|
| 500mg | $25 | In-stock |
| 1g | $40 | In-stock |
| 5g | $80 | In-stock |
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| Cat. No. : | HY-B0360 |
| M.Wt: | 370.79 |
| Formula: | C19H15ClN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Rebamipide (OPC12759) is an orally active gastroprotective agent that enhances the production of endogenous PGs (especially intragastric PGE2) by inducing COX-2 expression, thereby protecting the gastric mucosa from injury. Rebamipide exerts anti-proliferative activity against gastric cancer cells. Rebamipide can be used in studies of mucosal protection, gastroduodenal ulcer, gastritis and gastric cancer[1][2].
In Vitro: Rebamipide (1.4, 2.7, 5.4 mM; 24 h) inhibits proliferation of gastric cancer cell[1].
Rebamipide (5.4 mM; 30 min) activates Smad signaling pathway in AGS cells[1].
Rebamipide (5.4 mM; 3 h) induces the expression of Cdk inhibitor p21 in AGS cells[1].
In Vivo: Rebamipide (5, 15, 50 mg/kg; p.o.; once daily for 14 days) enhances the expression of COX-2 and PGE2, and protects gastric mucosa from acid-induced injury in rat gastric mucosa[2].
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