JI-101
CAS No. : 900573-88-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $615 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16265 |
| M.Wt: | 466.33 |
| Formula: | C22H20BrN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
JI-101 is an orally active multi-kinase inhibitor. JI-101 inhibits EphB4, VEGFR-2 and PDGFR-β. JI-101 exhibits anticancer activity. JI-101 can be used in research related to ovarian cancer[1][2].
In Vitro:JI-101 (10 μM; 0-30 min) exhibits high stability in mouse, rat, dog and human liver microsomes, with only 3.03-3.95% metabolism observed after 30 min of incubation[2].
JI-101 (1 μM; 15 min) is mainly metabolized by recombinant human CYP1A1 (with ~44% activity reduction) and CYP3A4 (with 10% activity reduction)[2].
JI-101 (10-100 μM; 0-120 min) efficiently penetrates the Caco-2 cell monolayer, with an efflux ratio of 0.32[2].
In Vivo:JI-101 (1-3 mg/kg; i.v. via tail vein; single dose; 10-30 mg/kg; p.o. by gavage; single dose) demonstrates 54.7% oral bioavailability in male Sprague Dawley rats, with preferential and persistent uptake in lung tissue[2].
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