Sodium carboxymethyl cellulose (Viscosity:1200-1400 mPa.s)

Sodium carboxymethyl cellulose (Viscosity:1200-1400 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent. In Vivo: Protocal for preparing 0.5% CMC-Na Solution
Measure 0.5g of dry CMC-Na and dissolved in 100 ml ddH2O/0.9% Saline (0.9 g NaCl in 100 ml ddH2O) to make a clear solution.
Under the condition of stirring and heating (50-65°C), adding CMC-Na slowly to ddH2O/0.9% Saline helps to accelerate dissolution.

Note
1.You must ensure that your CMC-Na solution does not exist solid-liquid separation phenomenon. The solution is in a uniform and transparent state has no particles in it.
2.Completely dissolution of CMC-Na may requires 4 hours or more longer.

In a pharmacological test, CMC-Na (oral;5% in water; 1 year) is well tolerated in rats^[2].
In an acute oral toxicity study in female mice, LD₅₀ of CMC-Na for female mice is 14 g/kg body weight of mice, equivalent to 9.8 g/kg body weight of rat, categorized as practically non-toxic according to Loomis criteria (LD₅₀ 5-15g/kg body weight of rat)^[3].