SEC inhibitor KL-2
CAS No. : 900308-51-2
(Synonyms: KL-2)
| Size | Price | Stock |
|---|---|---|
| 1mg | $68 | In-stock |
| 5mg | $85 | In-stock |
| 10mg | $136 | In-stock |
| 25mg | $285 | In-stock |
| 50mg | $456 | In-stock |
| 100mg | $730 | In-stock |
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| Cat. No. : | HY-123972 |
| M.Wt: | 333.74 |
| Formula: | C17H13ClFNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1]. IC50 & Target:SEC[1] In Vitro:SEC inhibitor KL-2 (20 μM, 6 hours) significantly slows Pol II transcription elongation rates and increases Pol II accumulation at promoter-proximal regions in HEK293T cells[1]. SEC inhibitor KL-2 (20 μM, 24 hours) significantly inhibits MYC transcriptional programs and RNA splicing-related gene expressions in HEK293T cells[1]. In Vivo:SEC inhibitor KL-2 (10 mg/kg, i.p., once daily for 15 days) delays tumor growth and prolonged survival in the MDA231-LM2 xenograft tumor model in nude mice[1].
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