Lobeline
CAS No. : 90-69-7
(Synonyms: α-Lobeline; L-Lobeline)
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| Cat. No. : | HY-B1423 |
| M.Wt: | 337.46 |
| Formula: | C22H27NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation[1][2].
In Vitro:Lobeline (0.1-100 μM) evokes [3H]DA overflow calcium-independently[1].
Lobeline inhibits [3H]DA uptake into synaptosomes (IC50=80 μM) and vesicles (IC50=0.88 μM)[1].
In Vivo:Lobeline (0.3-3.0 mg/kg; s.c.; single dose) decreases d-methamphetamine self-administration in rats model[3].
Lobeline (3 mg/kg; s.c.; 7 times during 7 sessions) specifically decreases responding for d-methamphetamine in a noncompetitive manner, and increases tolerance development[3].
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