3,4,5-Trimethoxycinnamic acid
CAS No. : 90-50-6
| Size | Price | Stock |
|---|---|---|
| 100g | $40 | In-stock |
| 500g | $142 | In-stock |
| 1000g | $277 | In-stock |
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| Cat. No. : | HY-W012123 |
| M.Wt: | 238.24 |
| Formula: | C12H14O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia
WILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
IC50 & Target: γ-subunit of GABAA receptor[2]
In Vitro: 3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
In Vivo: 3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1].
3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].
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