Xanthone

Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds^[1][2]. In Vitro:Xanthone relaxes the Norepinephrine (HY-13715)-induced contraction of rat thoracic aorta. The Norepinephrine and high-K⁺-induced vasoconstriction is inhibited dose dependently in aorta pretreated with Xanthone with IC₅₀ values of 60.26 μM and 82.9 μM, respectively^[1].
Xanthone concentration dependently inhibits the Ca²⁺ influx induced by either norepinephrine or high-K⁺, suggesting that Xanthone might act as a blocker of both receptor-operated and voltage-dependent Ca²⁺ channels^[1].
Xanthone causes an increase in the level of intracellular cyclic adenosine 3′,5′-monophosphate (cAMP), but not cyclic guanosine 3′,5′-monophosphate (cGMP) content^[1].