Quercetagetin
CAS No. : 90-18-6
(Synonyms: 6-Hydroxyquercetin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $123 | In-stock |
| 5mg | $260 | In-stock |
| 10mg | $390 | In-stock |
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| Cat. No. : | HY-N4149 |
| M.Wt: | 318.24 |
| Formula: | C15H10O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Quercetagetin (6-Hydroxyquercetin) is a flavonoid[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties.
IC50 & Target: IC50: 0.34 μM (PIM1), 3.45 μM (PIM2), 2.82 μM (RSK2), 21.2 μM (PKA)[1]
In Vitro: Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC50s of 3.45, 21.2, and 2.82 µM, respectively[2].
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM[2].
In Vivo: Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively[3].
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