ML348
CAS No. : 899713-86-1
(Synonyms: GNF-Pf-1127)
| Size | Price | Stock |
|---|---|---|
| 5mg | $79 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100736 |
| M.Wt: | 415.79 |
| Formula: | C18H17ClF3N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].
IC50 & Target: IC 50: 210 nM (LYPLA1)
In Vitro: ML348 (5 µM; 3 hours ) selectively inhibits LYPLA1 in cultured cells[1].
In Vivo: ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice[1].
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