Luseogliflozin
CAS No. : 898537-18-3
(Synonyms: TS 071)
| Size | Price | Stock |
|---|---|---|
| 1mg | $490 | In-stock |
| 5mg | $1225 | In-stock |
| 10mg | $1960 | In-stock |
| 25mg | $3955 | In-stock |
| 50mg | $6300 | In-stock |
| 100mg | $9800 | In-stock |
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| Cat. No. : | HY-10449 |
| M.Wt: | 434.55 |
| Formula: | C23H30O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Luseogliflozin (TS 071) is a potent, selective, orally active sodium-dependent glucose cotransporter (SGLT) 2 inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM). Luseogliflozin has the protential for researching type 2 diabetes[1][2].
IC50 & Target:IC50: 2.26 nM (SGLT2), 3990 nM (SGLT1)[1]
In Vitro:Luseogliflozin competitively inhibits the sodium-dependent uptake of 14C-α-methylglucoside by Chinese hamster ovary K1 cells overexpressing human SGLT2 in vitro (Ki value 1.10 nM)[1].
Luseogliflozin (20% OSI-096 (HY-10191) and Luseogliflozin-generated serum, 24 h) induces β-cell proliferation through a humoral factor-mediated FoxM1/PLK1/CENP-A pathway independent of insulin signaling[2].
In Vivo:Luseogliflozin (10 mg/kg, oral, 7 days) improves hyperglycemia and promotes β-cell proliferation in mice[2].
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