Aceclofenac
CAS No. : 89796-99-6
| Size | Price | Stock |
|---|---|---|
| 1g | $25 | In-stock |
| 5g | $50 | In-stock |
| 10g | $70 | In-stock |
| 25g | $110 | In-stock |
| 50g | $148 | In-stock |
| 100g | $195 | In-stock |
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| Cat. No. : | HY-B0634 |
| M.Wt: | 354.18 |
| Formula: | C16H13Cl2NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis[1][2].
In Vitro: Aceclofenac (1-30 μM; 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes[1].
Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreases by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test[1].
Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes[2].
In Vivo: Aceclofenac exhibits Cmax (4.59 μg/mL) following oral administration (rat 20 mg/kg)[3].
Aceclofenac exhibits terminal elimination half-life (rat 3.24 h) due to high plasma clearance (rat 1.10 L/h/kg) following intravenous injection (rat 10 mg/kg)[3].
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