Tazobactam (sodium)
CAS No. : 89785-84-2
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| 100mg | $50 | In-stock |
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| Cat. No. : | HY-W009168 |
| M.Wt: | 322.27 |
| Formula: | C10H11N4NaO5S |
| Purity: | >98 % |
| Solubility: | H2O : 250 mg/mL (ultrasonic) |
Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp..
In Vitro:Tazobactam sodium (0.045 mg/mL Piperacillin/Tazobactam, 3 days) causes oxidative stress and mitochondrial damage, leads to apoptosis in HK-2 cell with the combined use of Piperacillin (HY-B1923)[2].
In Vivo:Tazobactam sodium (300-500 mg/kg of Piperacillin/Tazobactam, iv, single dose) exhibits direct nephrotoxicity in C57BL/6 mouse models[2].
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