Inz-1

Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC₅₀=8.092 μM) over humans (IC₅₀=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in?the pathogenic fungus Candida albicans^[1]. IC50 & Target: IC50: 8.092 μM (yeast mitochondrial cytochrome bc1)
IC50: 45.320 μM (human mitochondrial cytochrome bc1)^[1] In Vitro: Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast?S. cerevisiae?(strain BY4741) and?C. albicans?(SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose^[1].?
Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both?S. cerevisiae and?C. albicans?with IC₅₀ value of 2.5 μM and 8.0 μM, respectively^[1].
Inz-1 (0-100 μM; 24 hours) is selective for yeast over human cytochrome bc1, it inhibits human cytochrome bc1 activity only weakly, with an IC₅₀?of 45.3 μM, 5.6-fold higher than the IC₅₀?for the?C. albicans?homolog in mitochondria purified from HEK293 human embryonic kidney cells^[1].
Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM，and only mildly at that concentration^[1].
Inz-1 is against candida, human enzyme with IC₅₀ values of 8.092 μM and 45.320 μM, respectively. It against Candida and HepG2 respiring growth with IC₅₀ values of 1.655 uM and >32 μM, respectively^[1].