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|---|---|---|
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| 500 mg | Get quote | |
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| Cat. No. : | HY-119956 |
| M.Wt: | 354.31 |
| Formula: | C16H18O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Biflorin has antimicrobial, antitumor, antiinflammatory and antimutagenic activities. Biflorin is found in the roots of Capraria biflora L[1][2][3].
In Vitro:Biflorin (72 h) inhibits tumor cell growth with IC50s ranging from 0.58 μg/mL (NCIH23 cell) to 14.61 μg/mL (MDA-MB-231 cell)[1].
Biflorin (3 and 6 μg/mL, 24 h) induces apoptosis, internucleosomal DNA fragmentation, mitochondrial depolarization in B16 melanoma cells[1].
Biflorin inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 macrophages via STAT1 Inactivation, with IC50 s of 51.7 and 37.1 μM, respectively[2].
Biflorin (5 and 10 μg/mL, 3 h) inhibits H2O2-induced oxidative damage by reducing lipid peroxidation and DNA damage in V79 mammalian cells[3].
In Vivo:Biflorin (25mg/day, i.p., for 10 days) inhibits tumor growth and increases the mean survival rate in B16 melanoma-bearing mice[1].
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