CM037
CAS No. : 896795-60-1
(Synonyms: A37)
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-110294 |
| M.Wt: | 431.57 |
| Formula: | C21H25N3O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C) |
CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC50=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics[1][2].
In Vitro:Cell viability and VEGF release experiments: CM037 (10 μM; 18 h) dose-dependently downregulates the expression and secretion of VEGF in MCF-7 cells and inhibited the proliferation and migration of endothelial cells[2].
Western blot experiment: CM037 (1 μM, 10 μM; 18 h) significantly reduces the levels of HIF-1α and VEGF proteins and blocked the RA/RAR signaling pathway[2].
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