VX-11e
CAS No. : 896720-20-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $119 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14178 |
| M.Wt: | 500.35 |
| Formula: | C24H20Cl2FN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM. In Vitro: VX-11e is active in the HT29 cell proliferation assay (IC50=48 nM)[1]. In Vivo: VX-11e is orally bioavailable in both rat and mice[1]. VX-11e (50 mg/kg, p.o.) results in robust inhibition of pRSK, and inhibits tumor growth in NSG mice bearing human melanoma RPDX tumors. VX-11e with BKM120 significantly improves tumor growth inhibition[2].
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