BMH-21
CAS No. : 896705-16-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $46 | In-stock |
| 10mg | $72 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $385 | In-stock |
| 500mg | $1320 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-12484 |
| M.Wt: | 360.41 |
| Formula: | C21H20N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic) |
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity[1][2].
IC50 & Target: DNA[1][2]
In Vitro: BMH-21 binds ribosomal DNA and inhibits Pol I transcription[1].
BMH-21 inhibits RNA polymerase I independent of DNA damage response[1].
BMH-21 intercalates into double strand (ds) DNA and has binding preference towards GC-rich DNA sequences[1].
BMH-21 (1 μM; 3 hours) acts in a DNA damage independent manner to activate nucleolar stress and RPA194 degradation[1].
In Vivo: BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo[2].
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