Lipoxin A4
CAS No. : 89663-86-5
(Synonyms: LXA4)
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| Cat. No. : | HY-113509 |
| M.Wt: | 352.47 |
| Formula: | C20H32O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].
In Vitro:LXA4 pretreatment (100 nM for 30 minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes[1].
Lipoxin A4 (LXA4) inhibits the expression of IL-6 and IL-8 in NHEKs[2].
Lipoxin A4 downregulates the expression of cyclin D1[2].
Lipoxin A4 also suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation of NHEKs[2].
LXA4 (100 nM; preincubation for 30 minutes)inhibits the proliferation of NHEKs with or without stimulating by LPS (10 μg/mL)[2].
In Vivo:Lipoxin A4 (intrathecal injection; 10-100 ng; 3 days) potently alleviates radicular pain in a rat model of non-compressive lumbar disc herniation[4].
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