LDN-212320
CAS No. : 894002-50-7
(Synonyms: LDN-0212320; OSU-0212320)
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $231 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $590 | In-stock |
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| Cat. No. : | HY-12741 |
| M.Wt: | 293.39 |
| Formula: | C17H15N3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC[1][2].
In Vivo: LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior[1].
LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC[1].
LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC[1].
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