Nortriptyline (hydrochloride)
CAS No. : 894-71-3
(Synonyms: Desmethylamitriptyline (hydrochloride); Desitriptilina (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 50mg | $60 | In-stock |
| 100mg | $80 | In-stock |
| 250mg | $130 | In-stock |
| 500mg | $175 | In-stock |
| 1g | $250 | In-stock |
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| Cat. No. : | HY-B1417 |
| M.Wt: | 299.85 |
| Formula: | C19H22ClN |
| Purity: | >98 % |
| Solubility: | H2O : 7.14 mg/mL (ultrasonic);DMSO : 83.33 mg/mL (ultrasonic) |
Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
In Vitro:Amitriptyline is metabolized by CYP2C19 to the active metabolite, Nortriptyline. Nortriptyline blocks the reuptake of Norepinephrine more potently than Serotonin[1].
Nortriptyline (6.25-100 μM; 24-72 h) hydrochloride markedly reducs the viability of TCCSUP and mouse MBT-2 bladder cancer cells in a concentration- and time-dependent manner[3].
Nortriptyline (12.55-100 μM; 24 h) hydrochloride induces cell cycle arrest and apoptosis in TCCSUP and MBT-2 cells[3].
Nortriptyline (12.55-100 μM; 24 h) hydrochloride induces both intrinsic and extrinsic apoptosis in these bladder cancer cells[3].
In Vivo:Nortriptyline (10-20 mg/kg; ip; every day; for three weeks) hydrochloride inhibits the growth of bladder tumors in mice inoculated with MBT-2 cells[3].
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