VU 0240551
CAS No. : 893990-34-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $156 | In-stock |
| 25mg | $329 | In-stock |
| 50mg | $560 | In-stock |
| 100mg | $896 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16689 |
| M.Wt: | 342.44 |
| Formula: | C16H14N4OS2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2]. In Vitro: VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner with 75 and 100 μM treatments causing a significant reduction in GABA-elicited hyperpolarization while 25 μM had no significant effect[2]. In Vivo: VU 0240551 (10 μM) significantly blocks the chloride influx in cells from Eu rats but did not affect cells from SL rats[3].
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