Imidaprilate
CAS No. : 89371-44-8
(Synonyms: 6366A; Imidaprilat)
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| Cat. No. : | HY-109592 |
| M.Wt: | 377.39 |
| Formula: | C18H23N3O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease. IC50 & Target: IC50: 2.6 nM (ACE)[1] In Vitro: Imidaprilate (6366A) is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM. Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC50 of 1.7 nM[1]. In Vivo: Imidaprilate (≥0.2 mg/kg) inhibits angiotensin I (AT-I)-induced pressor response. TA-6366 lowers the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5-2 mg/kg via oral administration, and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg[1].
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