GSK-269984A
CAS No. : 892664-04-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $640 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $2150 | In-stock |
| 100mg | $3400 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14467 |
| M.Wt: | 429.22 |
| Formula: | C20H14Cl2FNNaO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 7 mg/mL (ultrasonic;warming;heat to 60°C) |
GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC50 of 7.9. IC50 & Target: pIC50: 7.9 (Prostaglandin E2 Receptor 1 (EP1))[1] In Vitro: Results from [3H]-PGE2 binding assay in CHO cells overexpressing the human EP1 receptor demonstrate that GSK-269984A is an antagonist of EP1 receptor with a pIC50 of 7.9. GSK-269984A is found to cause a concentration-dependent rightward shift of the PGE2 dose-response curve and Schild analysis shows that GSK-269984A is a competitive antagonist with pA2 8.1±0.3 and slope 1.0[1]. In Vivo: GSK-269984A demonstrates an ED50 of 2.6 mg/kg (po), with the 10 mg/kg dose showing equivalent reversal of hypersensitivity to the standard. GSK-269984A displays moderate blood clearance in the rat and dog and high clearance in the monkey which is reflected in the half-life for each species[1].
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