AZD3988
CAS No. : 892489-52-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $770 | In-stock |
| 100mg | $1230 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-50861 |
| M.Wt: | 456.44 |
| Formula: | C23H22F2N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
AZD3988 is an orally active diacylglycerol acyl transferase-1 (DGAT-1) inhibitor. AZD3988 has excellent DGAT-1 (human) potency with an IC50 value of 0. 6 nM. AZD3988 can be used for the research of metabolic diseases such as diabetes, obesity[1]. IC50 & Target:IC50: 0.6 nM (h DGAT-1), 0.5 nM (Rat DGAT-1), 1.1 nM (Mouse DGAT-1)[1] In Vitro:AZD3988 (compound 53) (10 μM) can inhibit DGAT-1 with IC50 values of 0. 6 nM (human), 0. 5nM (rat), 1.1 nM (mouse) and 0.5 nM (HuTu 80 cell), respectively[1]. In Vivo:AZD3988 (compound 53) shows (i.v., p.o.; 0.5, 1, 2, 5 mg/kg) has good pharmacokinetics in vivo efficacy[1].
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