LY2334737
CAS No. : 892128-60-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $155 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $730 | In-stock |
| 100mg | $990 | In-stock |
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| Cat. No. : | HY-13672 |
| M.Wt: | 389.39 |
| Formula: | C17H25F2N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
LY2334737 is an nucleoside analog and is an orally active prodrug of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects[1][2].
IC50 & Target: Enterovirus A71 (EV-A71)[2]
In Vitro: Five cell lines that express CES2 responded to LY2334737 treatment. LY2334737 is less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells. The drug response of CES2-transfected HCT-116 cells correlated with CES2 expression level. Bystander studies show statistically greater PC-3-GFP growth inhibition by LY2334737 when cells are cocultured with CES2 and not mock transfectants[1].
In Vivo: Oral treatment of xenograft models with 3.2 mg/kg LY2334737 once a day for 21 days shows greater tumor growth inhibition of CES2 transfectant than the mock transfectant[1].
Metronomic LY2334737 administration causes increased blood flow in luciferase-tagged LM2-4 tumor xenografts, and this effect, readily measured using contrast micro-ultrasound, coincided with a relative increase in tumor bioluminescence[3].
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