BAMB-4
CAS No. : 891025-25-5
(Synonyms: ITPKA-IN-C14)
| Size | Price | Stock |
|---|---|---|
| 2mg | $160 | In-stock |
| 5mg | $250 | In-stock |
| 10mg | $375 | In-stock |
| 25mg | $675 | In-stock |
| 50mg | $945 | In-stock |
| 100mg | $1323 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16694 |
| M.Wt: | 252.27 |
| Formula: | C15H12N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 40 mg/mL |
BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer[1].
IC50 & Target: IC50: 37 μM (ITPKA); 20 μM (InsP3 kinase)[1]
In Vitro: BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM[1].
BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM[1].
BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake[1].
BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased V max [1].
BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity[1].
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