SIRT6-IN-2
CAS No. : 891002-11-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $950 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-103721 |
| M.Wt: | 366.32 |
| Formula: | C19H14N2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].
IC50 & Target:SIRT6[1]
In Vitro:SIRT6-IN-2 (200 μM) shows 100% inhibition of SIRT6 deacetylase activity, with an IC50 of 34 μM, and exhibits high selectivity for SIRT6 over SIRT1 and SIRT2[1].
SIRT6-IN-2 increases histone 3 lysine 9 (H3K9) acetylation in BxPC-3 cells to 1.9 times the level of vehicle-treated control cells[1].
SIRT6-IN-2 (100 μM; 18 h) enhances the uptake of the fluorescent glucose analog 2-NBDG in L6 cells to 1.4 times the control level[1].
In Vivo:SIRT6-IN-2 (5 mg/kg; i.p.) shows no obvious toxicity in ICR mice[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- SIRT6-IN-2
- Cat. No.:
- HY-103721
- Quantity:
Your information is safe with us.