ML349
CAS No. : 890819-86-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $790 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100737 |
| M.Wt: | 454.56 |
| Formula: | C23H22N2O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM[1][2].
IC50 & Target: Ki: 120 nM (APT-2)[1]
IC50: 144 nM (LYPLA2)[2]
In Vitro: ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively[1]. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells[3].
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