DC-05
CAS No. : 890643-16-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $320 | In-stock |
| 50mg | $1150 | In-stock |
| 100mg | $1750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12746 |
| M.Wt: | 383.49 |
| Formula: | C25H25N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.
IC50 & Target:IC50: 10.3 μM (DNMT1)[1]
Kd: 1.09 μM (DNMT1)[1]
In Vitro:DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively. DC-05 shows less potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM). DC-05 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h[1].
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- HY-12746
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